Abilitech Medical (Minneapolis, MN, USA) is building a suite of mobility devices to support the use of arms – the forgotten limb—in patients who live with MS, ALS, Muscular Dystrophy, spinal cord injury and stroke. A Class 1 device, Abilitech will gain access to a $2 billion market opportunity that grows to $7B in 2022. In 2023 Abilitech plans to enter the $20B stroke rehabilitation market with its ambulatory device. Abilitech will begin a Series B raise in December to fund sales expansion, clinical studies, and product development.

Therapeutic: Neurology

Access Vascular (Bedford, MA, USA) is developing a suite of venous access devices that use a new, patented biomaterial which is designed to prevent the most common and costly complications in the $4.4 billion global venous access market. Their first product, HydroPICC™ has demonstrated an average of 97% less thrombus accumulation on its surface compared to a standard polyurethane catheter. Access Vascular’s novel, bulk-hydrophilic material is designed to minimize the foreign body responses that leads to thrombosis and phlebitis.

Therapeutic: Biomaterials

Acoustic MedSystems, Inc. (AMS, Savoy, IL, USA) provides minimally and non-invasive therapeutic ultrasound devices for treatment of localized soft tissue diseases and pain. There is no other catheter-based interventional ultrasound ablative surgery product on the market. Uniquely precision directional and conformal surgery, short 2-15 min treatments, compatible with current clinical workflow.

Therapeutic: Minimally Invasive Surgery

AdjuCor (Munich, Germany) is a high-tech medical device company that has developed a disruptive technology for the long-term ambulatory treatment of end-stage heart failure patients, namely BEAT. After successful completion of acute and chronic (60-day survival) animal trials, AdjuCor is currently raising Series B financing to enable the first clinical application of BEAT within 12 months following investment. Thereby, it is set to become the world’s 1st commercially available, minimal invasive, biventricular, mechanical circulatory support device that also completely avoids blood contact.

Therapeutic: Cardiovascular

ADVITOS (Munich, Germany) has developed and commercializes the ADVOS therapy, the world’s first method for the combined multi-organ support of liver, lung, kidney, and blood pH correction. Multi organ failure is in 60% the cause of death on the ICU. ADVOS increases ICU patient survival from 10% up to 50%. ADVITOS has validated its business model in Germany (20 customers, 2m€ revenues 2019) and is currently fund raising to accelerate market expansion and penetration.

Therapeutic: ICU-Critical Care

Agile Devices (Boston, MA, USA) is commercializing novel coaxial deflection technologies for faster, cheaper and safer interventional procedures. Our first product in development, the Angler™ microcatheter, has been designed for peripheral, coronary and neuro vascular interventions. Our patented technology seeks to improve maneuverability with an actively controlled deflectable tip. This active tip control can potentially enable quicker vessel navigation and reduce guidewire and catheter exchanges. Key benefits may include reduced procedure time and cost, increased operating room availability, and improved patient outcomes.

Therapeutic: Interventional

AiM Medical Robotics (Ft. Lauderdale, FL, USA) is developing the world’s first MRI compatible surgical robot. Our surgical robotic platform simultaneously combines surgical planning and procedure with MR functional robotics that provide precise trajectory guidance for neurosurgical procedures. Our ability to provide predictable procedure planning is further enhanced by the system’s real time MR imaging support to compensate for movement of the target site during a procedure. As a Company, we aim to eliminate existing error and revision rates seen today, while reducing procedure time, to support better patient outcomes.

Therapeutic: Robotics

Alandra Medical (Mexico City, Mexico) is a clinical stage company developing the novel monitor ‘Florence’ to detect early signs of impaired perfusion and prompt timely interventions to break the vicious cycles that lead to shock in patients receiving Intensive Care. Unlike gold-standard perfusion markers that are readable through blood samples few times a day, ‘Florence’ allows surveillance of early signs of impaired perfusion through a simple feeding tube in real time. The company is raising Series B to launch the product in the US and EU to access a US$1.1Bn market.

Therapeutic: ICU-Critical Care

Alertgy’s (Melbourne, FL, USA) Non-Invasive Continuous Glucose Monitor utilizes machine learning and dielectric spectroscopy in a compact wearable, providing users with real-time blood glucose measurements, entirely pain-free.

Therapeutic: Diabetes

Alio (San Francisco, CA, USA) is an early commercial stage company who believes it is time we tap into the opportunity to revolutionize today’s tools for remote patient monitoring.  The technologies in the current market are invasive, expensive, often provide inadequate data and do not deliver a positive user experience.  Re-imagining what care looks like for those facing dialysis and heart failure has been done before, but the execution has failed. We understand chronic conditions do not merely require episodic care, but rather reliable and clinically accurate remote patient monitoring seamlessly integrating itself into a patient’s day to day life.

Therapeutic: Remote Patient Monitoring

Allotex (Boston, MA, USA) has developed an allogenic corneal inlay for the treatment of presbyopia. The use of human corneal tissue has overcome the previously seen problems encountered using synthetic inlays. We now have over one year follow up on a completed 100 patient Phase 2 study showing the safety and efficacy of this new modality.  Implanting the lenticule into the non-dominant eye has been shown to result in the preservation of excellent binocular distance vision and the restoration of natural reading vision.

Therapeutic: Ophthalmology

Amber Implants (Delft, South Holland, The Netherlands) VCFix (a "Breakthrough Device" by FDA) is the only cement-less solution for treating Vertebral Compression Fractures (VCFs). By omitting PMMA bone cement from the treatment process, VCFix aims to avoid all the primary and secondary complications related to bone cement which is up to 40%.

Therapeutic: Orthopedics-Spine

Analytics 4 Life (Cary, NC, USA) is combining digital health and machine learning to develop a novel, non-invasive cardiac diagnostic modality. With an initial focus on coronary artery disease, heart failure, and pulmonary hypertension, Analytics 4 Life is advancing the CorVista System, a point-of-care, radiation-free, and exercise-free diagnostic platform aimed at improving existing care pathways.

Therapeutic: Cardiovascular

AorticLab (Colleretto Giacosa, Italy) is committed to provide medical and technological innovations developing next generation devices for a safe and effective transcatheter treatment of the stenotic aortic native valve.

Therapeutic: Cardiovascular

AquaHeart inc. (Santa Ana, CA, USA) is developing a highly innovative, over-the-wire Single Shot PV Ablation system for the treatment of Atrial Fibrillation with real time electric block monitoring, powered by Steam. The system provides a fast, easy to use and safe catheter-based application of thermal energy to the PV ostium with proven achievement of electrical block in between 5 to 55s. Founded in 2018, the company is commencing to raise the equity A-Round of $10 million with the goal to complete the First in Human study in 2021.

Therapeutic: Cardiovascular

Armonica Technologies (Carlsbad, CA, USA) is an early stage medtech company focused on developing its proprietary long-read DNA sequencing technology for precision medicine applications. Today’s standard genome sequencing approaches require extensive library preparation and create a massive computational and bioinformatics problem related to reassembling the data set. Armonica’s technology uses proprietary nanochannels to deliver single DNA molecules through nanopores for optical readout by Raman spectroscopy, enabling direct sequencing of DNA, RNA and epigenetic modifications without the need for library preparation.

Therapeutic: Oncology - Rare disease

ART MEDICAL (Netanya, Israel) is on a mission to bring critical care into the 21st century and save lives by preventing ICU-acquired complications. The company has developed the smART+™ Platform, a personalized, all-in-one solution that prevents malnutrition, acute kidney injury, ventilator-associated events and pneumonia (particularly relevant to COVID-19 patients). ART MEDICAL is a pioneer of Nutrition Management 2.0™ and the only company on the market that complies with the new ESPEN guidelines regarding the calculation, evaluation and compensation of patients’ caloric needs.

Therapeutic: Critical Care

Atlantic Therapeutics (Galway, Ireland) develops professional and consumer medical devices, related software, apps and connected health technologies to treat all types of incontinence and other associated disorders by strengthening muscles and modulating nerves of the pelvic floor.

Therapeutic: Women’s Health

The AtmosThera (Oakland, CA, USA) soft hood system delivers personal oxygen therapy in a compact, noninvasive and mobile form factor that can escalate pressure to hyperbaric levels, which concentrates oxygen levels in the blood plasma. Like full hyperbaric oxygen chambers, it is useful in ARDs, as well as brain injuries resulting from trauma, stroke or infection. The automated treatment software gives it safe, reliable and simple operation. Patient outcomes are monitored by a paired mobile app and correlated with precisely verified treatment sessions.

Therapeutic: Respiratory

Auctus Surgical, Inc. (San Francisco, CA, USA) is developing a non-fusion spinal implant system - known as a vertebral body tethering system(VBT) - to correct pediatric scoliosis. The system incorporates a dynamic magnetic technology permitting a child’s spine to be non-surgically adjusted over time. The endoscopic procedure may eliminate the need for long term bracing as well as many traumatic fusion surgeries.

Therapeutic: Orthopedics-Spine & Pediatrics

Azalea Vision (Ghent, Belgium) is a Health-Tech spin-off initiative currently incubating at imec/UGent. It is developing a fully encapsulated platform with an artificial iris embedded in an off-the-shelf contact lens. Potential patients are those who suffer from iris deficiencies, high order aberrations, and light sensitivity or photophobia, a common, yet debilitating symptom seen in many neuro-ophthalmic disorders. The iris aperture automatically adapts to light conditions through concentric rings on an integrated liquid crystal (LC) cell. The smart contact lens will operate for an entire day thanks to ultra-low power design.

Therapeutic: Ophthalmology

Beta-O2 (Rosh-Haayin, Israel) The ßAir Bio-Artificial Pancreas provides a viable and safe environment for pancreatic cells inside a subcutaneously implanted bioreactor. Consequently, they can thrive, function like native cells thus providing the body with the two essential hormones at the correct ratio. The device is able to do so as Beta-O2 has solved the two major challenges of islet transplantation – adequate oxygen supply and full immune-protection. At the same time, the diabetic patient is freed from risky and morbidity-inducing immune-suppressive drugs therapy. Evidently, this platform technology can be adopted as to maintain any future source of hormones secreting cells.

Therapeutic: Diabetes

BioSculpture Technology, Inc. (West Palm Beach, FL and New York, NY, USA) is a commercial stage medical device company focused on focusing on fat aspiration, processing, and autografting methods and devices. It is developing a minimally invasive treatment of Obesity and Type 2 Diabetes that has the potential of doing for obesity management what LASIK did for vision correction.

Therapeutic: Minimally Invasive Surgery

BSL Regenerative Stemcell Technologies Inc. (Goyangsi Kyonggido, South Korea) Adinizer Smart Kits are the most advanced, regenerative adipose-tissue and mechanical stromal cell processing devices using Adinizers, various sizes of the exclusive patented sharp blade-edge micropore filtering systems. Automatic Cell Station is the winner of 2019 IFATS enzymatic SVF device competition session.

Therapeutic: Regenerative Medicine

Cala Health (Burlingame, CA, USA) is a bioelectronic medicine company transforming the standard of care for chronic disease. The company’s wearable neuromodulation therapies merge innovations in neuroscience and technology to deliver individualized peripheral nerve stimulation, and its vertically integrated commercial model is reshaping the delivery of prescription therapies. Cala Health’s lead product, Cala Trio™, is the only non-invasive prescription therapy for essential tremor.

Therapeutic: Neuromodulation

Capri-Medical (Dublin, Ireland) Injectable treatment to prevent migraine. With a micro invasive design, Capri-Medical's solution, provides superior patient comfort while delivering advanced technical performance.

Therapeutic: Neuromodulation-Neurostimulation

CardiacBooster A.V. (Nijmegen, Netherlands) addresses the pVAD market with a novel device concept. With barely half of cardiogenic shock patients surviving despite support with current percutaneous ventricular assist devices (pVAD), a substantial unmet clinical need remains and time is ripe for innovation. CardiacBooster’s differentiated technology creates a powerful pump within the left ventricle. The device adds stroke volume and cardiac output by actively ejecting blood from the left ventricle. The novel concept allows for a low-profile catheter design while preserving power, overcoming the trade-off existing devices have to make between pump power and size-related access complication.

Therapeutic: Cardiovascular

Cardiawave (Paris, France) is a clinical-stage company which has developed a unique NON-INVASIVE, real-time image-guided medical device to treat aortic stenosis with focused ultrasound.

Therapeutic: Cardiovascular

CardioRenal (Paris, France) is a company dedicated to improving the quality of treatment for heart failure patients through the use of state-of-the art technology (expert systems, real-time diagnosis, microfluidics, etc.) combined with top medical expertise.

Therapeutic: Cardiovascular

Ceek (Portland, OR, USA) is a women’s health company focused on creating products for better gynecological exams. Nella is the first major innovation of a vaginal speculum, a device used ~60-million times annually and not updated in 150-years. The VuSleeve is a novel product to retract vaginal side walls during exams and to protect tissue during electrocautery procedures. VuLight is an innovative universal single-use light that works with any speculum. We have won 3 major design awards: FAST company, IF, and Core77 awards.

Therapeutic: Women’s Health

CeQur Simplicity™ (Boston, MA, USA) ensures mealtime insulin is always within reach. Convenient, discreet, 3-day wearable insulin Patch for injection-free dosing, clinically shown to improve A1C and time-in-range. It is easy to teach, learn, and use. A compact, slim design enables the Patch to be worn and dosed under clothing.

Therapeutic: Diabetes

Chronus Health (Mountain View, CA, USA) is building an affordable, CLIA waived point-of-care blood testing device to accelerate medical decision making in multiple clinical settings. Their initial commercial device launch will measure complete blood count (CBC) and comprehensive metabolic panel (CMP), which account for 50% of all blood tests performed in the United States.

Therapeutic: Diagnostics

CivaTech Oncology® (Research Triangle Park, NC, USA) designs innovative products that bring meaningful improvements to low dose rate brachytherapy. The CivaString® and CivaSheet™ can substantially reduce procedure time, provide homogeneous dose distribution and minimize trauma. Customizable CivaTech products insure that radiation oncologists can deliver individualized, targeted therapy to treat cancer.

Therapeutic: Oncology

CorInnova (Houston, TX, USA) is commercializing a revolutionary non-blood contacting biventricular cardiac assist device for the treatment of acute heart failure that would eliminate many adverse events associated with existing cardiac assist devices. CorInnova’s device, initially for the fast-growing short-term cardiac assist market (< 7 days’ use), will expand the serviceable market by 50%, to $6B+.

Therapeutic: Cardiovascular

CorWave's (Clichy, France) mission is to save heart failure patients and offer them an active life. We have developed a breakthrough technology that can transform the LVAD Bn$ market and introduce a paradigm shift in heart failure therapies. Working with world-class clinicians in the US and Europe, CorWave has the potential to change the standard of care. CorWave's ambition is to become a new global leader in medtech with the support of top-tier investors and taking advantage of the LVAD unique market structure.

Therapeutic: Cardiovascular

CPR Therapeutics Inc. (Putney, VT, USA) is developing the first integrated, advanced technology, automated CPR system (called the CPR-T System). The goal is to produce a medical device that performs a precision complex combination-type of CPR that provides much greater blood flow to the heart and brain. This should re-start hearts at a much higher rate, while protecting the brain from injury. The CPR Therapeutics automated CPR device (the CPR-T System) is intended to be an integrated, synchronized, and optimized platform that combines several known single technology improvements and techniques and builds upon them with advancements and new technologies.

Therapeutic: Cardiovascular

CroíValve (Dublin, Ireland) is an early stage medical device company focused on developing a percutaneous solution for severe tricuspid regurgitation which is safe, effective, easy to use & treats all patients.

Therapeutic: Cardiovascular

Day Zero Diagnostics (Boston, MA, USA) uses whole genome sequencing and machine learning to modernize infectious disease diagnosis and treatment. DZD is developing a rapid diagnostic for sepsis that uses genomic data to identify a pathogen and to comprehensively profile its antibiotic resistance, as well as services for hospital infection control. Our goal is to modernize hospital microbiology using NGS and a big-data approach.

Therapeutic: Diagnostics

Diality Inc. (Irvine, CA, USA) is a privately held medical device company developing a smart, flexible, portable hemodialysis machine that will enable patients to self-treat at home or wherever they travel. Diality is committed to improving the quality of life of patients with kidney disease and are developing a versatile hemodialysis solution that reduces the patient and caregiver burden of care and burnout, allowing more patients to benefit from their prescribed dialysis treatment at home or in a variety of care settings.

Therapeutic: Renal

Divvy Tree (Bristol, CT, USA) is an integrated caregiving platform that aggregates healthcare, home care and lifestyle supports through voice-action and AI technologies. Divvy Tree lessens the burden on caregivers helping them to improve quality of life, better cooperation, and enhance care outcomes. Real-world evidence based on real-time patient reported outcomes is the inherent by-product of the platform.

Therapeutic: Artificial Intelligence

Dymicron, Inc. (Orem, UT, USA) is a privately held, innovative medical device company that is advancing a new generation of musculoskeletal implant devices made from polycrystalline diamond — one of the strongest substances known to man. Triadyme-C is a motion-preserving artificial cervical disc that emulates the complex coupled motion of a natural spinal disc while providing stability throughout the range of motion. The exceptional durability of polycrystalline diamond virtually eliminates the risks of wear debris for the lifetime of the patient.

Therapeutic: Orthopedics-Spine

Earlens Corporation (Menlo Park, CA, USA) was founded to address the growing demand for hearing loss solutions with an innovative, proprietary, ENT medical focused solution which combines superior performance and sound quality with a patient-focused, concierge approach to care. The Earlens contact hearing solution uses a custom built “Lens” transducer which is placed on the eardrum by an ENT physician and adjusted to the needs of the patient by an audiologist. This unique approach provides practice differentiation, attractive profit margins and delighted patients.

Therapeutic: ENT & Hearing

EchoPixel's (Santa Clara, CA, USA) True3D is the first software platform that empowers physicians with a 3D Interactive holographic experience of standard CT, MRI and live Angiography and Echo images, that simplifies surgical, minimally invasive and robotic procedures.

Therapeutic: Augmented Reality

Eclipse Regenesis, Inc. (Menlo Park, CA, USA) is developing the first restorative therapy to address pediatric and adult Short Bowel Syndrome (SBS), a malabsorption disorder caused by a lack of functional small intestine. Current chronic therapies for SBS include expensive medication and intestinal surgery, which come at a staggering average 5-year cost of $1.6M per patient. Via distraction enterogenesis, the Eclipse XL1 System is able to harness the body’s own tissue regenerative capabilities to produce new, fully functional intestine in vivo.

Therapeutic: Gastroenterology & General Surgery

Embody LLC (Norfolk, VA, USA) is a sports medicine medical device company developing collagen-based implants for the treatment of tendon and ligament injuries. Embody will launch the Tapestry Biointegrative Implant following FDA 510(k) clearance in October 2020. Embody will launch four products over the next three years. Embody has been funded by DARPA and the Department of Defense with over $20 million in non-dilutive funding and has previously raised $9.3 million in Series A financing. In 2021, we are seeking $15 to 20 million Series B funding to accelerate commercial adoption and product development.

Therapeutic: Orthopedics-Spine & Soft Tissue Repair

emtensor (Fremont, CA, USA) produces a novel brain scanner for detecting ischemic and/or hemorrhagic brain conditions using a portable, safe, fast and early deployable functional brain imager that can radically reduce the time from onset to treatment in stroke from hours to minutes. Harmless non invasive radio frequency measurement coupled with a no moving part modality and no contrast agents is combined with full electromagnetic wave solution based tomography to identify regions of unhealthy tissue inside the skull from the tissues tell-tale relative permittivity characteristics.

Therapeutic: Stroke, Traumatic Brain Injury, Transient Ischemic Attack, Concussion & Brain Health

Endiatx (Redwood City, CA, USA) proudly debuts PillBot™, our quad-pumpjet equipped swimming robot, which provides a doctor with a live video feed and an XBOX controller to perform active upper endoscopies totally sedation-free, and in your street clothes. All you do is skip breakfast, drink a glass of water, and swallow our pill, and your doctor can immediately look around inside you like never before! We’ve been swallowing passive pill cameras for 23 years now; isn’t it time they moved around and did things?

Therapeutic: Gastroenterology & Pill Robots

EndoShape (Boulder, CO, USA) is a venture-backed company seeking to improve embolization procedures for patients and physicians through the application of advanced polymer technology and unique device design. We are focused on the embolization and occlusion market and seek significant physician guidance as we engage in robust product development and commercialization activity. 

Therapeutic: Vascular

Enspectra Health (Mountain View, CA, USA) is a tissue imaging company, developing a miniature pulsed laser microscope, that allows a clinician to look through the surface of living tissue, non-invasively. We are initially bringing this innovation to Dermatology in the form of a handheld, real-time, high-resolution skin imaging system for the detection of non-melanoma skin cancers. In addition to Dermatology, we are targeting the detection and characterization of tumor tissue within the fields of Gastroenterology, Surgical Oncology and Gynecology.

Therapeutic: Imaging

ErgoSuture (Boston, MA, USA) Drive'N Roll is an advanced suturing system with the simplicity of a regular needle driver that offers improved maneuverability and needle handling, short learning curve and shorter procedure times.

Therapeutic: Urology, Gynecology & Minimally Invasive Surgery

E-Scopics S.A.S (Aix-en-Provence, France) E-Scopics dematerializes Ultrasound to democratize its use to all healthcare professionals. Products are application specific Apps, downloadable on Tablets or Smartphones that connect to, and control smart digital probes. E-Scopics truly revolutionizes the field of Ultrasound, leveraging advance processing techniques and AI-based imaging algorithms. This allows ultra-low power consumption systems, addressing the key issue of all ultraportable systems on the market. E-Scopics further differentiates clinically with unique “imaging biomarkers” that standardize surveillance of chronic diseases, without acquisition skills nor interpretation expertise.

Therapeutic: Imaging & Diagnostics

ExplORer Surgical (Chicago, IL, USA) the leading platform for intraoperative surgical and interventional procedure workflow management and analytics, improves communication and performance in the OR. ExplORer helps medical device companies and procedure teams reduce variability and bring best practices to life by providing a customized digital playbook software for use during procedures. ExplORer can be used in-person or remotely through real-time audio and video guidance.

Therapeutic: Digital Health, Teleproctoring and Remote Care

Eyedetec Medical, Inc. (Danville, CA, USA) Dry Eye Disease significantly impacts quality of life, is highly prevalent, and the incidence is growing 7% annually (30M patients in US, 350M worldwide). Time spent on digital screens is accelerating this increased incidence. There is currently no cure, and available devices create fear, anxiety, and often pain among patients, and are costly. Eyedetec Medical is developing a patented, non-invasive medical device with novel mechanisms of action for treating these patients, that is effective, soothing, and relaxing. Proof-of-concept clinical data is positive. Eyedetec also has an early commercial product called EyeGiene, and a product website is available (www.eyegiene.com).

Therapeutic: Ophthalmology

At Eysz, (Piedmont, CA, USA) we are building a digital health platform that measures disease progression, intervention efficacy and side effects to assist clinicians in developing a personalized care plan for epilepsy and then advance it to other neurological diseases.

Therapeutic: Neurology & Digital Health

FA Corporation (Lincoln, RI, USA) introduces the World’s first laser-based anti-aging solution, safe and effective for ALL skin types. Powered by IP protected MID IR Fiber laser system, our solution has the highest safety margin generating immediate and long-lasting results in 1 treatment. Today, existing laser solutions are limited to lighter skin, and are not suitable for Asian or darker skin due to significant unwanted side effects. Our solution will open up Asian and darker facial rejuvenation demand creating opportunities for rapid growth.

Therapeutic: Aesthetics-Dermatology, General Surgery & Ophthalmology

FAST BioMedical (Indianapolis, IN, USA) is a private, late clinical stage medical technology company focusing on development and commercialization of a patented technology for quantifying clinically relevant parameters that have been challenging or impossible to measure in the past. The Company is currently developing first in class technology for quantifying volume status and kidney function in a clinically actionable timeframe. FAST BioMedical's technology could have a significant impact on the treatment of patients with heart failure, acute decompensated heart failure, cardiorenal syndrome, sepsis, acute kidney injury (AKI) and major suregery patients .

Therapeutic: Cardiovascular

FineHeart (Pessac, France) The patented FineHeart invention, the ICOMS (Implantable Cardiac Output Management System) is a novel, wirelessly powered, fully implantable mechanical circulatory support device able to optimize cardiac output while preserving the heart’s innate contractility. It is a game-changing therapy for long term circulatory assistance in severe heart failure patients.

Therapeutic: Cardiovascular

Forest Devices (Pittsburgh, PA, USA) has developed AlphaStroke, the first technology that has been shown to accurately detect stroke in the prehospital environment. With AlphaStroke, paramedics can take the right patient to the right hospital, as soon as possible. Reducing delays in stroke treatment decreases both permanent disability and health care costs.

Therapeutic: Stroke

Francis Medical (Maple Grove, MN, USA) Water vapor ablation technology, a breakthrough therapy, is designed to kill cancerous prostate tissue using a minimally invasive trans-urethral procedure performed in an outpatient setting. The technology utilizes phase-shift energy in water vapor to transfer thermal energy convectively to cancerous prostate tissue causing irreversible cell death while minimizing damage to surrounding structures like nerves by respecting the prostate's natural boundaries. Desired outcomes include few to no side effects like incontinence and erectile dysfunction which are typical with current treatments.

Therapeutic: Urology & Prostate Cancer

As an affiliate of Johns Hopkins University, Galen Robotics (Baltimore, MD, USA) in conjunction with Johns Hopkins Robotics Lab, have developed a surgical robotic assistant to fill a large unmet need in microsurgical procedures. The Galen Surgical Platform (GSP) is designed to assist surgeons by providing tool stabilization, intelligent safety barriers and guidance during microsurgery. The GSP system supports the Neurosurgery, Head & Neck and ENT markets.  The Galen is designed to assist the surgeon without interruption to their existing workflow and is uniquely designed to hold a range of existing surgical instruments.  GSP enhancements that are in development include intelligent capabilities, augmented reality (AR) navigation and real-time data analytics. The Galen management team brings a blend of high-tech, big data analytics and clinical/medical experience, which supports their development teams’ ability to iterate new features quickly while remaining sensitive to the demands of the regulatory environment for medical devices. Galen expects FDA approval and a commercial launch in 2021.  

Therapeutic: Robotics & Surgery

GATT Technologies’ (Nijmegen, The Netherlands) hemostats and sealants focus on controlling severe surgical bleedings as well as preventing and treating organ leakages. Leveraging its patented technology, our company has developed a synthetic surgical and sealant platform with the potential to become a superior alternative to the current fibrin and PEG-polymer based solutions in terms of speed, efficacy and cost. Currently, we are focusing on moving GATT-Patch, a fast hemostatic sealing patch to be used in general surgery, into clinical trials in Europe and the United States. Additionally, we are further developing other pipeline products including GATT-Powder (hemostat, laparoscopic use) and GATT-Tape (intestinal anastomotic leakage) and we are assessing other potential applications based on our activated polyoxazoline technology such as uses in bone regeneration, anti-adhesion, vascular, and ophthalmological procedures.

Therapeutic: Surgery

Gordian Surgical (Misgav, Israel) has developed and commercialized the TroClose™ 1200 – an integrated port closure system offering surgeons a simple, secure and safe solution to open and suture close the abdominal wall during laparoscopic procedures. Failure to properly close access ports results in hernias that effect patient quality of life and add significant costs to healthcare providers. TroClose, with CE Mark and FDA approval, has been successfully used in > 200 hospitals and > 3000 patients globally. Worldwide commercialization commenced in 2019.

Therapeutic: Surgery

G-Tech Medical (Mountain View, CA, USA) Wireless, wearable patch system that records myoelectric signals from the digestive tract as a measure of gastrointestinal motility, to aid in the diagnosis of digestive disorders such as Irritable Bowel Syndrome and Inflammatory Bowel Disease, and to monitor GI dysfunction such as occurs following major surgery.

Therapeutic: Diagnostics

Haermonics (Eindhoven, The Netherlands) cleans the pericardial cavity after open-heart surgery to prevent complications. Current standard care after open-heart surgery causes activated and contaminated blood and clots to remain in the pericardial cavity. This retained blood causes complications such as occluded drains, excessive blood loss, reoperations for bleeding and postoperative atrial fibrillation. Haermonics patented technology continuously flushes the pericardial cavity with a saline solution. Haermonics flush is successfully proven as published in eBiomedicine, published by the Lancet.

Therapeutic: Surgery

Handylife SA (Lausanne, Switzerland) is a profit-making Swiss eHealth company founded in 2009 by Dr E. Lucas. The company offers a new generation of electronic health record (EHR) software to medical practices, hospitals and clinics in Switzerland and soon, across the globe. The competitive advantage of Handylife relies on the superior technological modularity, adaptability and agility of its solution, fully compatible with a scalable digital platform model. Furthermore, the company’s pricing strategy favours repetitive sales, recurring revenues and a repeatable sales cycle.

Therapeutic: Electronic Health Record (EHR) Software

Healionics (Seattle, WA, USA) is a clinical-stage company addressing the critical need for improved means of dialysis access in patients with kidney failure. Our STARgraft vascular graft (artificial blood vessel) resists the problems of occlusion and infection suffered by current grafts. We also have an exciting product pipeline based on our platform STAR® biomaterial which, given its unique ability to prevent both scarring and infection, can enable new types of implantable devices and improve the performance of many existing ones.

Therapeutic: Renal & Biomaterials

HemoCath (Toronto, Ontario, Canada) intelligent heart failure monitoring platform will transform treatment for patients with heart failure (HF), to reduce hospitalisation and rehospitalization.  Hemocath medical device is a diagnostic & monitoring pulmonary artery (PA) catheter with multiple microsensors communicating with a secure cloud for remote patient monitoring (SaaS, AI, machine learning). HemoCath provides real-time actionable clinical data guiding cardiologists  -  reducing hospitalisation and rehospitalization.  HemoCath (4F) is easily inserted into a vein on the upper arm and flow-directed to the PA. Clinical studies with PA monitoring have shown a 39% reduction in HF hospitalisation and a 59% reduction in HF 30-day readmissions.

Therapeutic: Cardiovascular, Diagnostic & Patient Monitoring

HiCura Medical Pte. Ltd. (Singapore) Most neuraxial procedures such as epidural and spinal anaesthesia are performed blindly, leading to multiple needle insertions and increased risk of complications. Our product, uSINE, has the potential to transform the current way clinicians are performing neuraxial procedures. With uSINE’s automated real-time identification of the spinal landmarks during ultrasound scans, clinicians are able to pinpoint the right needle entry point and angle for needle insertion. uSINE has been proven to be effective on two clinical studies on 150 patients.

Therapeutic: Artificial Intelligence

HigoSense (Warsaw, Poland) is a revolutionary telemedicine solution that gives a diagnosis within one hour, based on the collected physical examinations. Thanks to Higo - patients collect medical data themselves: they measure the temperature, auscultate the heart and lungs, take photos of the throat, ear and skin. The patient receives a diagnosis, information on what to do next, as well as an e-prescription, e-referral and e-release. All this at home, without the need for direct contact, without the risk of infection.

Therapeutic: Telemedicine

iDENTICAL (Mountain View, CA, USA) is revolutionizing tooth replacement with drill-free dental implants. By using 3D technology and our patent pending approach, we're able to make a dental implant that’s shaped almost identically to the patient's original tooth root. Within two weeks of a tooth extraction, a dentist can simply insert the iDENTICAL implant into the existing socketsite. Our drill-free solution is non-invasive, faster and more affordable than dental implants in the market today and can be provided by any dentist.

Therapeutic: Dental

Imago Systems, Inc. (Lansdowne, VA, USA) is a privately-held C-corporation, incorporated in Delaware. The Company has created a multi-dimensional visualization and characterization software for the post-processing of digital images to elucidate their content. The software reveals information that is present but normally not visible, or is difficult to identify, helping professionals to better interpret the content.

Therapeutic: Imaging

Implandata Ophthalmic Products GmbH (Hannover, Germany) 80 million patients are at risk of permanent loss of eyesight because of glaucoma. Management of glaucoma patients is primarily eye center based. Disease status and progression is unknown in between office visits, resulting in irreversible vision loss at a significant number of patients. Implandata’s breakthrough EYEMATE system introduces remote management and care of glaucoma. Crucial disease parameters are collected at the patient, AI analyzed and provided real-time to the ophthalmologist, enabling personalized therapy guidance.

Therapeutic: Ophthalmology & Digital Health

InnAccel Technologies (Bangalore, Karnataka, India) Fetal Lite is a next generation, AI-powered, fetal heart rate (FHR) monitor, based on fetal ECG signal extraction technology. This technology is superior, in terms of accuracy, reliability, and ease of use, to conventional ultrasound-based technology. FL will enable doctors and nurses to provide more comfortable and more efficient monitoring for patients. Key Features: Single probe to measure fetal heart rate, maternal hear rate, and uterine contractions. Standard probe positioning (no need to localize fetal heart) with no belts. Proprietary, high-sensitivity electrode technology. Data viewing and storage on detachable tablet through wireless connection. Remote data access for home and remote monitoring. Fetal Lite is CE certified.

Therapeutic: Women’s Health

InterShunt (St. Louis, MO, USA) is developing a proprietary transcatheter system that allows for the capture and excision of tissue from the interatrial septum. The result is a left to right atrial shunt that off-loads elevated left atrial pressure, reducing symptoms in Heart Failure patients. The mechanical system is designed for safety and ease of use and is the only interatrial shunting device that requires no implant and no energy. 

Therapeutic: Cardiovascular

InVatin Technologies is a MedTech company developing revolutionary solutions for stroke prevention. InVatin was founded by Dr. Nussinovitch during his service as a hyperbaric physician in the Israeli Navy in order to prevent the devastating outcomes of embolic stroke in high risk patients. The company has recruited a leading team of engineers and works with experienced GLP-approved facilities in which the SYNAXIS device is being manufactured and tested.

Therapeutic: Cardiovascular

Ischemia Care (Dayton, OH, USA) uses blood testing for stroke in the acute hospital setting when a patient presents with stroke and stroke symptoms. ISCDx stratifies patients by cause (ex cardioembolic, atherosclerosis, atrial fibrillation) to reduce cost and improve care resulting in reduced risk for recurrent stroke. ISCDx change in care is 40% of strokes never have cause determined (“cryptogenic”) leading to increased cost and higher recurrence risk. Completed 1700 patient clinical trial (BASE) to commercialize multiple tests covering entire stroke care continuum.

Therapeutic: Diagnostics

Kube Innovation (Montreal, QC, Canada) created a bite force measuring device for dental clinicians. It provides key information, in order to choose the best treatment and prevent failures. The Innobyte also creates a better outcome for patients in less time since up to 40% of dental repairs are currently failing. We have partnered with Henry Schein Canada for a distribution partnership since September 2020. We are the first mover in a $5B worldwide market with an innovative technology protected patent and trade secrets.

Therapeutic: Dental

LeukoLifeDx (Point Pleasant, NJ, USA) is a medical diagnostic company developing a new genomic assay that will guide the treatment of Heart Failure, saving 80,000 lives and $3 billion annually, by identifying the 20% high-rise patients who should be directed to medical therapy rather than surgery.

Therapeutic: Cardiovascular

LifeSignals (Fremont, CA, USA) helps you bring your product concept to life quickly and efficiently. Our LSP-based subsystems can be rapidly designed to meet OEM-specific needs, with programmable on-chip application processors for controlling radios and sensor interfaces, and for implementing desired sensor data algorithms.

Therapeutic: Patient Monitoring

LifeWave Biomedical (Los Altos, CA, USA) is developing a connected care solution that improves the clinical management of patients living with congestive heart failure (CHF) in hospital and home settings. The CardioConnect platform features a small, non-invasive lung sensor that provides a direct measurement of lung fluids for managing and optimizing CHF patient fluid balance. The sensor is coupled to a smartphone and cloud application that provides insights for guided-therapy and hospitalization decision support. The expected benefits of the system are reduction of health care costs associated with hospitalization and re-admissions and improvement of patient quality-of-life.

Therapeutic: Cardiovascular & Remote Care

Lightpoint (Cambridge, MA, USA) is developing miniaturized sensing and imaging tools for robot-assisted cancer surgery. The company has two robotic probe technologies in development which aim to aid surgical decision making, improve patient outcomes, and save costs for healthcare systems. Although applicable to a wide range of major cancer types, the first commercial focus is prostate cancer surgery. Lightpoint has secured over $17M in non-dilutive grants and $10M in private investment with early commercial sales in the UK, Netherlands, and Germany.

Therapeutic: Oncology

The COVID-19 crisis cruelly highlighted the need to improve access to clinical diagnosis. Loop Medical's (Lausanne, Switzerland) vision is to simplify access to clinical-grade blood testing for everyone, everywhere, and to unlock the tremendous potential of home testing. We are developing a painless, easy-to-use sampling device that collects a large volume of high-quality capillary blood (1 mL vs. only 0.2 mL for competitors). It is supported by the Bill & Melinda Gates Foundation, by the Horizon 2020 programme and partners with Cerba Healthcare.

Therapeutic: Diagnostics

Materna Medical (Mountain View, CA, USA) What if you could reduce pelvic floor damage, incontinence, and pelvic pain by 60%, removing over $2.2B of cost from women’s healthcare annually? Materna Medical is revolutionizing women's pelvic health with first-to-market medical devices. Materna's first product, Milli, launched in 2019 to treat pelvic pain, and pipeline product, Prep, reduced pelvic floor injury by 60% and is in a $2.2M NIH-funded pivotal trial to prevent pelvic floor damage during childbirth. Combined, these devices define a $6B market in women's health.

Therapeutic: Women’s Health, Obstetrics, Gynecology, Physical Therapy

Medela AG (Baar, Switzerland) is the global manufacturer of medical vacuum solutions trusted by healthcare professionals around the world. As you develop therapies of tomorrow, Medela's Partnering Unit can support you with our best-in-class medical suction technology. Medela’s partnerships include customizing solutions for global market leaders spanning a multitude of therapeutic areas including, Women's Health, Endoscopy, Thrombectomy, Aesthetics and more. Please reach out to learn more about Medela’s various levels of integration and end-to-end vacuum solutions.

Therapeutic: Customized & OEM Medical Vacuum

The Melzi (Los Altos, CA, USA) Sharps Finder is used by open, laparoscopic, and robotic surgeons to locate hard to find suture needles or sharps lost in the surgical area. The Sharps Finder addresses patient safety concerns while reducing surgical time and expense and minimizing risk exposure.

Therapeutic: Minimally Invasive Surgery

MetriTrack’s (Hillside, IL, USA) technology relies on the dynamic mapping of the deforming breast tissue during ultrasound scanning, made possible by actively tacking anatomical references and the ultrasound probe with small electromagnetic sensors enclosed in proprietary body attachment parts. The sensors’ output is processed using proprietary algorithms and software to precisely map the breast tissue and guide the operators to obtain complete and optimal exams. Metritrack’s software and sensor-based suite of products is designed to integrate with all existing breast ultrasound systems in use globally.

Therapeutic: Imaging

MicroElastic (Durham, NC, USA) is building the data-driven future of precision skincare by developing a handheld ultrasound device called Bullseye™ that provides precise measurements of skin elasticity at the touch of a button. Elasticity is a key indicator of skin health and aging used by clinicians and manufactures of aesthetic skincare therapies. Current methods of measurement such as pinching, suction, and compression, are unreliable and cannot target the dermis. MicroElastic is currently launching a demo fleet of devices for evaluation by strategic partners.

Therapeutic: Aesthetics-Dermatology

Micro-Leads Medical (Somerville, MA, USA) is a neuromodulation technology company developing a high-resolution and precision directional neurostimulator platform with an initial indication to improve the treatment of chronic pain. Our disruptive targeting technology delivers therapeutic stimulation to two-times more neural targets with greater pinpointing accuracy for maximizing the therapeutic window without side effects. Micro-Leads technology is designed to provide pain relief for multiple indications where conventional treatment has provided inadequate or short-lived pain relief. The closed-loop platform is also extendable to peripheral nerve and brain stimulation.

Therapeutic: Neuromodulation-Neurostimulation, High-resolution & Targeted Delivery

Microsurgical Innovations (MSI) (Salt Lake City, UT, USA) designs and develops leading-edge medical devices for use in microsurgical and macrosurgical applications. MSI's first product to be commercialized is, its Vascular Coupling System (VCS), which is intended to replace the hand suturing technique currently being used to connect arteries and veins in microvascular and macrovascular end-to-end vascular repair surgeries.

Therapeutic: Neurovascular

MinInvasive Ltd. (Holon, Israel), founded in 2011, is a privately held MedTech company developing its OmniCuff™ System platform – a single-patient use device enabling arthroscopic, needle-based rotator cuff repair (RCR) that obviates the need for suture anchors. The company has conducted a successful post-market study, established a manufacturing facility to support mass production, and initiated limited market release in the United States.

Therapeutic: Orthopedics

Miracor Medical SA (Awans, Belgium) is a medical device company developing disruptive solutions to treat severe heart diseases; striving to bring back cardiac patients to normal life. The company was founded in May 2008 by Professor Dr. Dr. Werner Mohl and the European venture capital firms Earlybird and Delta Partners. Miracor develops and commercializes the PiCSO (Pressure-controlled Intermittent Coronary Sinus Occlusion) Impulse System, a technology platform designed to improve clinical outcome of patients with impaired cardiac function.

Therapeutic: Cardiovascular

Modulim (Irvine, CA, USA) delivers transformative optical solutions that help people live healthier, longer lives. Our first product, the Clarifi® Imaging System, is intended for patients with potential circulatory compromise. Clarifi is powered by Spatial Frequency Domain Imaging (SFDI), a patented optical technology that enables rapid non-contact microvascular assessment of tissue hemoglobin oxygenation and distribution. SFDI hemoglobin biomarker maps quantifies potential circulatory compromise to help clinicians provide multidisciplinary care that reduce the number of limb complications caused by diabetes and peripheral arterial disease.

Therapeutic: Digital Biomarkers, Diabetes & PAD

MOWOOT (Barcelona, Spain) is the first Intermittent Colonic Exoperistalsis (I.C.E.) device on the market, solving a huge unmet need for patients with intestinal transit disorders. Inspired by professional colonic massage, the MOWOOT system applies sequential pressure waves alongside the large intestine to physically move the feces and induce the natural colonic secretion. Clinically proven positive results in Neurogenic Bowel Disorder, Opioid-Induced constipation and Chronic Idiopathic Constipation, with as little as 15 minutes daily treatment. CE certified Class IIa medical device.

Therapeutic: Gastroenterology

Nanochon (Burke, VA, USA) is developing a 3D printed soft implant for treating knee injury. The device replicated cartilage tissue for both fast rehab and log term healthy cartilage regeneration. The device is also 18X cheaper than current options.

Therapeutic: Biomaterials

NanoDx Inc. (Southborough, MA, USA) is a privately held medical device company developing novel and rapid point-of-care technologies for the objective diagnosis and management of concussion and other traumatic brain injury (TBI). The company’s lead product, the NanoDx™ blood test, delivers biologically based results shown to confirm a concussion accurately in less than 90 seconds. BioDirection’s platform utilizes a patented bio-nanowire technology with the potential for use in a range of applications in point-of-care diagnostics. The NanoDx™ System for COVID-19 addresses existing diagnostic challenges by providing a rapid assessment from a finger stick of blood or saliva sample in a 2 minute test – all in a simple, low-cost system that includes a portable handheld, analyzer, disposable cartridges and secure software for seamless systems integration.

Therapeutic: Diagnostics

Nasus Medical (Mountain View, CA, USA) is developing a novel drug delivery platform that is delivering steroids directly to the target anatomy implicated in Chronic Rhinosinusitis. This intervention will enable patients to treat themselves noninvasively at home, early in the disease, to improve quality of life, and help them avoid unnecessary provider visits, medications, and procedures.

Therapeutic: ENT & Drug Delivery

NeoMedLight (Villeurbanne, France) Through photobiomodulation, CareMin650 provides treatment for mucositis and dermatitis induced by radio / chemo therapy. Mucositis and dermatitis are massive unmet clinical needs impacting the life of many cancer patients. Light has proven under strict parameters to prevent those serious side effects of cancer treatment. NeoMedLight’s unique technology of fabric emitting light allows a photobiomodulation treatment, operator independent and controlled , compatible with hospital logistics and adding value to the healthcare system.

Therapeutic: Oncology & Photobiomodulation

Neuraptive Therapeutics (Philadelphia, PA, USA) is a biotechnology company focused on improving outcomes in peripheral nerve repair. Our lead program, NTX-001, is a unique drug/device combination that has shown, when used as an adjunctive therapy with standard nerve repair surgery, the ability to prevent Wallerian degeneration is axons distal to injury. We are currently enrolling patients in a Ph 2a study and have received Fast Track Designation from the US FDA. We are actively raising a Series B financing.

Therapeutic: Surgery & Peripheral Nerve Repair

Niche Biomedical Inc. (Los Angeles, CA, USA) is a private-held medical device company spun-off from UCLA in 2016. The company is developing a set of novel technologies and devices to support various wireless closed-loop neuromodulation on center, peripheral, autonomous/enteric nervous systems as electroceuticals and prosthetic devices to treat diseases/injuries untreatable pharmacologically.

Therapeutic: Neuromodulation-Neurostimulation

Ninety One (New York, NY, USA) is a cloud-native and AI technology company aspiring to lead the transformation into digital healthcare and personalized medicine. It was founded on the conviction of fusing medical science with advanced mathematical modelling and big data technology. The first solution is an augmented intelligence, SaaS ecosystem automating and redesigning remote monitoring of implanted cardiac devices and wearables – in partnership with foremost research and healthcare institutions in the US, Europe, and Asia. A cloud platform that automates the collection of data and reports from implanted cardiac devices and wearables – digitizes, structures, and analyzes them with applied data science – in a single-point, easy-to-use interface for patient care and innovation in research.

Therapeutic: Digital Health

Noscendo GmbH (Duisburg, Northrhine-Westfalia, Germany) offers a completely new way of identifying pathogens. Through a paradigm shift based on proprietary algorithms and software harnessing next-generation sequencing, Noscendo identifies pathogens from patient samples.

Therapeutic: Diagnostics

nView medical (Salt Lake City, UT, USA) is a startup with a mission to make surgery safer, faster, and consistently accurate. nView develops imaging systems, bringing breakthrough AI solutions for image creation, image processing, and image visualization to surgery and interventional radiology.

Therapeutic: Imaging & Image Guidance

ODS Medical Inc. (Montreal, Quebec, Canada) is dedicated to bringing the next generation of diagnostic tools to the hands of physicians by bringing together the power of machine learning and molecular imaging to develop optical biopsy tools based on Raman spectroscopy. The SentryTM system for real-time tissue characterization detects the presence of invasive cancer directly in patients, pushing the limits of cancer detection in many procedures. and empowering doctors to make critical decisions, in real-time, to improve patient safety and outcomes.

Therapeutic: Surgery

Omics Global Solutions (San Juan, Puerto Rico - USA territory) developed INNOVATIO ND2 and started the commercialization of it in Latin countries this year and is looking for investors and strategic partners to reach the global potential in a Smart and Organized way. INNOVATIO ND2 is the 1st blood test in the world able to Identify the risk of developing Renal Disease in Type 2 diabetic patients. This IP Protected technology with Global potential arrived to help doctors, patients and payers to Prevent Diabetic population to reach dialysis and save million of lives!

Therapeutic: Diagnostics & Diabetes

OncoRes Medical (Perth, Western Australia, Australia) is transforming the standard of care in breast cancer surgery, which today leaves 1 in 5 patients requiring a repeat operation. Our in-cavity imaging system uniquely intensifies a surgeon’s sense of touch, improving surgical accuracy and facilitating confidence in complete tumour removal the first time. This will eliminate the substantial physical, psychological, and economic burdens associated with repeat breast cancer surgeries around the world.

Therapeutic: Surgery & Oncology

Osseoprint3D (Millburn, NJ, USA) was founded by dental implantologist, Dr. Arthur Greyf to address the lack of efficient surgical solutions for restoring adequate bone structure needed for placing dental implants. He and his team have optimized the process of the surgical planning, 3D modeling and aseptic 3D printing for bone grafts for dental and medical applications. These innovations bring cost efficiencies, time savings and improved clinical outcomes for patients and practitioners.

Therapeutic: Dental & Oral Surgery

PEDRA Technology (Singapore) brings precision data into angiographic suites, via clinically demonstrated real-time non-invasive perfusion monitoring of foot tissue perfusion. We have raised US$6.15M in seed/Series A financing, and seek investors for our Series B with a target closing in 2021Q1. Our current lead investor is a corporate strategic with a global footprint in peripheral vascular devices and other medical equipment. We have an experienced team with a proven record of efficient cash management. FDA has confirmed our 510(k) approval pathway, and we are targeting 2021Q3 for our first 510(k) approval. Our technology will benefit patients with peripheral artery disease, critical limb ischemia and diabetic foot ulcers.

Therapeutic: Cardiovascular & Diabetes

PercuSense (Valencia, CA, USA) is focused on developing next generation continuous sensing platforms that enable prediction, intervention, and prevention in chronic diseases and acute conditions including diabetes management and in-hospital monitoring. PercuSense’s unique technology enables low-cost monitoring of a variety of analytes, including glucose, lactate, oxygen, and ketones, to bring affordable and actionable continuous monitoring to the market. PercuSense’s vision is to provide the right information in the right moment in order to improve outcomes, cost, and burden in settings and diseases across the healthcare spectrum.

Therapeutic: Digital Health, Diabetes & Patient Monitoring

Perfuze (Galway, Ireland) is an interventional neurovascular company founded in 2018 to commercialize technology designed to treat Acute Ischemic Stroke (AIS). Our unique catheter technology platform is designed to achieve superior clinical outcomes in shorter procedural times; resulting in fast, safe, cost-effective clot extraction from the brain. To date, €11m in funding has been secured (50% non-dilutive). The lead investors are EarlyBird HealthTech (Berlin, Germany) and HBM-MedFocus (Irvine, CA, USA).

Therapeutic: Neurovascular

Phagenesis (Manchester, UK) has developed Phagenyx to treat dysphagia – the inability to swallow. Dysphagia causes severe complications after mechanical ventilation and affects 60% of patients that have been orally intubated or tracheotomized. There is currently no effective treatment available in the ICU. Phagenyx is based on 25 years of cutting edge research. Phagenyx is CE marked, in the US Phagenyx was designated Breakthrough Device and we expect De Novo approval early 2021. Based on the attractive Phagenyx margin profile we are currently preparing for US commercialization.

Therapeutic: Neuromodulation-Neurostimulation

Piomic Medical (Zürich, Switzerland) develops innovative medical devices for the treatment of hard-to-heal wounds, based on the proprietary COMS® therapy. The CE marked COMS® Therapy System incorporates the technology for concurrent optical and magnetic stimulation. COMS® One is an ultraportable device, intended to promote wound healing in chronic leg and foot ulcers. The therapy integrates smoothly into the patient’s healing journey, with applications in stationary and ambulant facilities but also in patient’s homes. This innovative approach is enabling patient self-management and saved significant health care costs in its multicentric pivotal trial (n=40).

Therapeutic: Wound Management

Pixium Vision (Paris, France) The PRIMA System compensates vision loss for atrophic dry AMD patients, it features a miniaturized and wireless sub-retinal implant, a pair of glasses and a pocket processor equipped with breakthrough algorithms.

Therapeutic: Ophthalmology

PK vitality (Paris, France) K’Watch is a Continuous Glucose Monitoring device in a form of a smartwatch and a patch with microneedles. It is painless, invisible to others and provide better insights thanks to its multiple sensors.

Therapeutic: Diabetes & Biomarkers

Pops (Minneapolis, MN, USA) is a leader in the democratization of healthcare through a platform centered around Mina, an AI-driven virtual coach in the users' smartphone to self-manage diabetes. People don’t want to be remotely managed as patients. They want a consumer-oriented experience they can use in real-time, while they live their life. Mina is surrounded by simple consumer-experience sensors, starting with a glucose meter that is the simplest way to measure blood glucose on the market. People can now manage their diabetes 24x7, with a consumer experience they expect.  Pops is commercialized in a B2B business model with health plans and employers. 

Therapeutic: Digital Health

Poseidon Medical Inc. (Hollywood, FL, USA) is a pre-commercial stage private medical technology company focused on developing and commercializing percutaneous implants for the treatment of Left Main lesions. In the USA, 20% of patients diagnosed with this life-threatening disease are ineligible for surgery and no interventional option is approved. Poseidon is well positioned to produce the first device with an FDA indication to solve this significant unmet need.

Therapeutic: Cardiovascular & Interventional Cardiology

PreciHealth SA (Neuchâtel, Switzerland) a Swiss-based MedTech company offering a true first-in-class breakthrough for the rapidly expanding pre-filled auto-injectors and blood sampling market.

Therapeutic: Drug Delivery

Promaxo (Oakland, CA, USA) is a medical technology company that develops and commercializes customer-centric MRI systems and MRI based technologies that enhance patients' lives and redefine the standard of care. Using our proprietary technologies protected by 55+ patents, we are bringing the first MRI and robotic-guidance system for in-office use.

Therapeutic: Imaging

Provisio Medical (San Diego, CA, USA) has developed a novel smart catheter technology, Sonic Lumen Tomography (SLT), that provides precise real-time flow lumen dimensions and can be integrated directly into the type of therapeutic catheters physicians are already using. Delivering the size and shape of a vessel lumen without the cost, time, and complexity of conventional endovascular imaging, Provisio’s SLT is designed to revolutionize interventional therapy by giving physicians the exact information that they need, when they need it, while improving workflow and outcomes.

Therapeutic: Interventional

Proximie (London, United Kingdom) saves lives by sharing the world’s best clinical practice by connecting clinicians on a global scale and combining them with advanced technologies, like Augmented Reality, Machine Learning and Artificial Intelligence, so they receive real-time insight to deliver optimal patient care. Proximie is a global company, deployed in over 35 countries and over 150 hospitals. Our footprint in the US is growing exponentially, by year end it will account for over 50% of our business, as we reach 300 deployments globally.

Therapeutic: Telemedicine & Augmented Reality

Radiance Therapeutics (Tucson, AZ & Bay Area, CA, USA, London, UK) is commercializing an innovation from University College London/ Moorfields Eye Hospital to address the critical unmet need of high failure rates in glaucoma filtration surgery. The RadianceTx device utilizes beta therapy; a therapeutic modality clinically proven in Randomized Controlled Trials to significantly improve glaucoma surgical outcomes. This disruptive technology has the potential to revolutionize the treatment of glaucoma; RadianceTx is a compelling opportunity to enter the growing ophthalmic device market with a lead technology.

Therapeutic: Ophthalmology

Rapid Medical (Yokneam, Israel) is developing and commercializing game-changing devices for the endovascular treatment of stroke. Endovascular stroke treatments are promising and have already shown to be effective in limited subgroups of patients. We are focused on further developing these treatments by developing and commercializing superior devices that will benefit more stoke patients. For example, we are making the only device in the world that is approved for the treatment of medium sized stroke causing occlusions in the brain.

Therapeutic: Neurovascular

Rehaler ApS (Copenhagen, Denmark) is bringing to market the disruptive idea of treating acute migraine with aura by controlling the body’s CO2 content – a highly efficacious mechanism proven in academic research but which has not been practically possible or safe until the development of Rehaler ApS’s patented and award-winning technological solution, Rehaler®. Rehaler has been tested in a clinical pilot, CE-approved and is now in use by more than 1500 patients in Denmark. A large-scale clinical trial is currently being planned.

Therapeutic: Pain Management

Sana Health (Boulder, CO, USA) At home pain and mental health relief; audio-visual neuromodulation clinically proven to lower pain, anxiety and depression. Going through pivotal trials for Fibromyalgia at Duke, and Neuropathic pain at Mount Sinai. On market as a wellness device already.

Therapeutic: Pain Management & Mental Health

Saranas (Houston, TX, USA) is a privately held medical device company focusing on improving patient outcomes through early detection and monitoring of internal bleeding complications. The Early Bird® Bleed Monitoring System for vascular access procedures enables physicians to mitigate downstream consequences by addressing bleeds immediately before they become complications, improving patient outcomes and lowering healthcare costs.

Therapeutic: Interventional

The Savonix (San Francisco, CA, USA) vision is a world without dementia.  We deliver a fully mobile assessment of cognitive function available on Android and iOS for phone and tablet. Savonix Mobile is an accurate, accessible and affordable tool for professional cognitive screening. It empowers healthcare providers, payers and researchers to evaluate and leverage results to improve health and treatment outcomes. Led by clinical neuro-psychologists, neuroscientists and IT leaders, Savonix sets the global standard on cognition and its relationship to risk, health outcomes and the development of innovative therapies. Savonix evidence-based tests are digitally validated versions of the gold standard cognition tests, many of which neuropsychologists have used effectively since the 1930s.

Therapeutic: Digital Health

Sense Neuro Diagnostics (Cincinnati, OH, USA) Sense Diagnostics has developed technology that can 1) detect and distinguish between all stroke subtypes in pre-hospital and emergency department environments, and 2) monitor ongoing brain injury susceptible to expanding hemorrhage accurately, objectively, continuously and in real time. Our initial focus is on stroke and traumatic brain injury, where time to proper treatment is critical, and delays can result in disability or death. We have developed one device to effectively triage patients in the field and ED by determining stroke by subtype and bleeding from a TBI, and another for monitoring in the Neuro ICU.  Sense technology performs a single scan of 720 data points in 2.5 seconds, and detects bleeds as small as 1 ml.

Therapeutic: Neurovascular

SentiAR (St. Louis, MO, USA) is developing the first application of Mixed Reality technology for use during cardiac ablation procedures, including the treatment of atrial fibrillation. The SentiAR platform provides an immersive command-center for the clinicians by presenting a 3D hologram of the patient’s electroanatomic data via the Microsoft HoloLens in real-time. Our solution gives the clinician unprecedented control via SentiAR’s patent protected, intuitive gaze interface and provides invaluable insight to guide physician diagnosis and catheter placement.

Therapeutic: Cardiovascular

Senzo (Los Angeles, CA, USA) has developed the most sensitive testing platform for any protein available to date.  Able to measure as low as femtogram/ml levels of analyte, the platform is mobile and fast as well as accurate.  While currently applying the platform to the COVID-19 pandemic, being able to measure both antigen and antibody, the platform has many other potential opportunities, including but not limited to cancer biomarkers, work that has been successful, hormones, cardiac biomarkers and more.  

Therapeutic: Diagnostics

At Side Sleep Technologies (Amsterdam, The Netherlands) we're trying to replace the NUMBER 1 most prescribed pill for the last 20 years with a patented medical device that will eliminate nighttime heartburn reflux symptoms by using sleep positional therapy.

Therapeutic: Gastroenterology

Smart Meter, LLC (Tampa, FL, USA) is streamlining connected care with a platform of cellular connected devices, data transmission, and digital portals enabling telehealth and remote patient monitoring. These innovative solutions optimize chronic care management with immediate, real-time communication between patients and physicians.

Therapeutic: Diabetes

Sonavex, Inc. (Baltimore, MD, USA) is a clinical stage spin-out from Johns Hopkins with FDA-cleared technology to improve arteriovenous fistula (AVF) maturation for patients with end stage renal disease. Despite the fact that the superior method of AV access for the 4.9M patients projected to be on dialysis by 2025 is an AVF, they fail to mature in 50% of procedures and are rendered unsuitable for dialysis. This results in significant catheter-based dialysis and associated bloodstream infections, costly hospitalizations and increased mortality. Every additional catheter day costs more than $125 per patient per day. Volumetric flow rate has been proven to be predictive of AVF maturation, however the specialized skill set required to operate conventional ultrasound limits its use in this patient population. Sonavex’s technology enables any member of the care team to rapidly collect volumetric flow rate, diameter, and depth in just seconds via a bioresorbable implant (EchoMark) with >90% margins and an automated 3D ultrasound (EchoSure).

Therapeutic: Imaging

Sonic Incytes (Vancouver, BC, Canada) is a health technology company founded in 2017. Recognizing the rise of chronic liver disease, Sonic Incytes has made it its mission to reduce the disease by enabling routine assessment and improved management of liver health. Its breakthrough, point of care ultrasound solution, VelacurTM , is redefining the standard of care in quantifying chronic liver disease—with diagnostic accuracy comparable to MRI.

Therapeutic: Diagnostics, Imaging & Gastroenterology

Soovu Labs (Seattle, WA, USA) has developed a personalized, drug-free, at-home chronic pain relief therapy that uniquely taps physiological and psychological. Soovu's combination of digital health App, AI, and non-invasive neuromodulation is proven effective in clinical trials and long-term in-home-user-trials. The receptor TRPV1's role in detecting inflammation and dangerous heat is integral to pain. Soovu's proprietary wearable pulses heat to desensitize cutaneous TRPV1 receptors, providing prolonged all day pain relief. While our App aids in addressing chronic pain's intensifying comorbidities, stress, and anxiety.

Therapeutic: Pain Management & Digital Health

Spark Biomedical, Inc. (Dallas, TX, USA) is a medical device company and developer of the Sparrow Therapy System™, a wearable neurostimulation solution for opioid withdrawal relief. Building upon a solid history of neurostimulation therapy, Spark applied over 150+ years of combined neuroscience and medical device expertise to advance the level of care through an evidence-based approach. Our goal is to provide a safe and effective path forward so more patients can overcome fear, heal from withdrawal, and achieve a better-quality life.

Therapeutic: Neurostimulation-Neuromodulation & Opioid Withdrawal

Tada Medical (Stockholm, Sweden) specializes in need-based product develop. The company's first product, ReLink(R), is a safety connector for IV tubes with the potential to reshape the IV therapy landscape. ReLink(R) will increase global patient and nurses safety in both human and veterinary care.

Therapeutic: Drug Delivery

Tel-Array Diagnostics (Vancouver, BC, Canada) was founded by two scientists, Drs. Hong Zhang and William Campbell, and incorporated in November 2013. Since then, the Company has set-up a fully functional assay development facility located at the University of British Columbia. The Company capitalized on its highly sensitive protein microarray technology platform to develop the Spot Profiler™, a portable, in vitro diagnostic (IVD) platform medical device for point-of-care testing (POCT). The Spot Profiler™ is capable of multi-marker testing on a single patient sample for expanded diagnostic window and improved diagnostic accuracy and speed. It is the first system with an expandable testing menu, allowing for flexibility in marker selection and breadth in diagnostic application. The Spot Profiler™ combines the advantages offered by the specificity of antibodies, the sensitivity of microarrays, the precision of active microfluidics, and the simplicity of optical detection.

Therapeutic: Diagnostics, Cardiology & Oncology

Terapede Systems (Campbell, CA, USA) will provide advanced diagnostic and health benefits to patients with the next generation of X-ray imaging Flat Panel detectors (FPD) used by doctors, interventionalists and surgeons for the diagnosis of disease, minimally invasive treatment of vascular disease, and other, non-vascular disease. This solution provides: Better image quality (2x to 5x higher resolution), fewer false positives, improved outcomes, and reduced treatment costs, 40% reduction in dose - static image quality, 2x to 3x reduction in dose - Fluoroscopy/Dynamic imaging, lower cost – Approximately 30-50% of comparable solutions in the market today, patented and proven design utilizing 3-D semiconductor and MEMS technologies enabling a novel 4-sided tileable block, commercial and financial agreement in place with market leader, Varex Imaging.

Therapeutic: Imaging

Theranica Bio-Electronics LTD (Netanya, Israel and NJ, USA) is a prescribed digital therapeutics company dedicated to creating effective, safe, affordable, low-side effect electroceuticals for idiopathic pain conditions. The company's award-winning flagship product, Nerivio®, is the first FDA-cleared smartphone-controlled prescription wearable device for acute treatment of migraine. Setting the foundation of an effective first-line therapeutic alternative to pharmacological options within the migraine industry, Theranica is expanding its proprietary technology to offer additional solutions for other pain conditions. The Nerivio has received FDA authorization for use in acute treatment of migraine and is currently under review by FDA for use in chronic migraine.

Therapeutic: Neuromodulation-Neurostimulation

Tivic Health Systems Inc. (Menlo Park, CA, USA) Tivic Health is a commercial-stage medical technology company that develops bioelectronic devices to treat chronic diseases. Tivic Health’s first product in market, ClearUP Sinus Pain Relief, is a non-invasive handheld neuromodulation device that is targeting the $130 billion cough, cold, and allergy market. ClearUP efficacy outperforms many over-the-counter drugs and is comparable to intranasal corticosteroids, with a superior safety profile. ClearUP is FDA-cleared and CE marked for over-the-counter sale, which together provide access to markets in over 190 countries.

Therapeutic: Neuromodulation-Neurostimulation

VALFIX Medical (Tel Aviv, Israel) is developing the first complete transcatheter solution that combines repair and replacement treatments for Heart Failure patients suffering from significant Functional Mitral Regurgitation (FMR), offering a viable alternative to open-heart surgery. VALFIX’s innovative technology enables mitral valve repair and replacement in one transcatheter procedure. In the US and the EU alone, there are more than 3 million FMR patients that require an intervention. This market is growing rapidly and is estimated to exceed $4 billion by 2025.

Therapeutic: Cardiovascular

ViCentra (Utrecht, The Netherlands) is the home of Kaleido, the world's smallest and lightest insulin pump for people with type 1 diabetes. Its unique patented pump technology drives an extremely accurate delivery and has a very favorable disposable cost of goods. Kaleido comes with 2 rechargeable pumps and a wireless handset and is available in 10 vibrant colors. It is designed for easy to use consistent performance, allowing people with diabetes to live life on their own terms.

Therapeutic: Diabetes

Vivasure Medical (Galway, Ireland) is developing a range of solutions for areas of unmet clinical need, with particular focus on arterial and venous closure devices, based on its patented PerQseal® technology. Its lead product is the world’s first fully absorbable, patch-based large-bore percutaneous closure device. This new, easy-to-use device is designed to enable closure of large arteriotomies in transcatheter procedures such as those used for Transcatheter Aortic Valve Replacement (TAVR) and Endovascular Aneurysm Repair (EVAR).

Therapeutic: Cardiovascular

Voyant Diagnostics (Moutain View, CA & Chicago, IL, USA) is developing solutions that improve the efficiency and accessibility of diagnostic services. ALFRED is a self-service platform that performs a range of routine, rapid diagnostic tests across biofluids. Patients are often unable to access rapid diagnostics tests when seeking virtual care. Voyant's patient- or caregiver-initiated device can be deployed in community-based settings to facilitate on-demand testing and expand diagnostic access.

Theraputic: Diagnostics

X-BOLT Trauma (Dublin, Ireland) Designed for complete ease-of-use, X-BOLT’s portfolio has a strong base of intellectual property, regulatory approvals and have been the subject of two significant and successful multi-center RCTs that showed better patient outcomes and ultra-low reoperation rates. The X-BOLT trauma portfolio now includes femoral, humeral and tibial nailing as well as hip fixation. We also have a spinal pedicle X-BOLT. All incorporate strong fixation, fast and fun operating; resulting in cost savings for hospitals, quicker and better recovery for patients.

Therapeutic: Orthopedics-Spine