The SteriPlas Cold Plasma medical device by Adtec Healthcare Ltd (Twickenham, London UK) is a strong antibacterial with proven clinical efficacy for the management of chronic wounds, LVAD driveline infections, diabetic foot ulcers and deep sternal wound infections typically complicated with biofilm. Where conventional therapies, such as antibiotics, fail to destroy bacteria protected within biofilm leading to a worsening infection, the SteriPlas delivers a quick, painless and fast-acting solution to physically destroy all forms of bacteria regardless of their resistance profile.

Therapeutic: Wound Management; Infection control

The ANA5 system from Anaconda Biomed (Sant Quirze -Barcelona- Spain) is intended to be inserted and navigated to the neurovascular anatomy. The funnel is deployed by retracting the conduit catheter and is intended, when deployed, to provide temporary vascular flow restriction. The device is indicated for restoring blood flow in patients experiencing an acute ischemic stroke due to large vessel occlusion.

Therapeutic: Stroke; Mechanical Thrombectomie

Introducing Artedrone: The groundbreaking robotic platform revolutionizing stroke treatment. Through autonomous mechanical thrombectomy, it targets large vessel occlusions, a crucial procedure for stroke patients. Addressing a critical global need, it aims to expand access to life-saving treatment for millions. With stroke prevalence increasing, its innovative approach holds immense market potential, addressing a healthcare burden exceeding $100 billion annually. By integrating micro-robotics, imaging, and AI, Artedrone's platform offers end-to-end procedure automation, showcased through successful in-vivo experiments.

Therapeutic: Neurovascular

Augmedit (Naarden, the Netherlands) develops AI-driven Augmented Reality technology that elevates surgical precision, improves preparation, offers immersive medical training, and engages patients and families in understanding complex procedures. We aspire to making surgeries safer and more efficient and transforming the healthcare experience for both providers and patients.

Therapeutic: Augmented Reality; Artificial Intelligence

Vita AV by AVeta Medical (Galway, Ireland) is a non hormonal therapeutic medical device for the treatment of Vaginal Atrophy.

Therapeutic: Women’s Health; Menopause / GSM/ Vaginal Atrophy

Axis Spine Technologies (Leeds and St Albans, UK) is pioneering spinal alignment through modular precision. We provide surgeons with a next generation implant that offers an off-the-shelf, bespoke patient solution. Its revolutionary wedge-within-a-wedge design allows for atraumatic insertion to achieve and maintain superior spinal alignment for improved clinical outcomes. The Axis-ALIF is on sale in the US and generating excellent results. Axis is seeking additional funds to scale up its commercialisation efforts and complete the development of a full portfolio using this patented technology.

Therapeutic: Minimally Invasive Surgery; Spine Surgery

Beyeonics Surgical (Tirat Carmel, Northern District, Israel) is a pioneering medical technology company poised to fundamentally transform the operating room landscape. We leverage cutting-edge augmented reality (AR), surgical navigation, 3D Robotic Exoscope, data processing, AI and digital platform technologies to empower surgeons across multiple specialties. As a spin-off from Elbit Systems, the company has strong roots in F-35 aviation technology and clinical experience with a commercial-stage sister company in ophthalmology (Beyeonics Vision). We are currently focused on spine and brain neurosurgery and orthopedics.

Therapeutic: Orthopedics-Spine; Neurosurgery-Brain, Augmented Reality, Minimally-Invasive Surgery

RoboticScope, a revolutionary surgical microscope crafted by BHS Technologies (Innsbruck, Austria), integrates a head-mounted display, a 3D camera mounted onto a 6-axis robotic arm, and advanced computing capabilities, redefining the landscape of surgical microscopes. BHS Technologies is a full-scale organization with over 40 employees, holding ISO 13485 certification and FDA listing. The device has obtained CE marking and FDA approval, has been commercially available since the mid-2020. More than 3,000 surgeries have been performed, with many more to come.

Therapeutic: Minimally Invasive Surgery

Colospan (Israel) introduces a novel device for colorectal surgery that aims to prevent the profound clinical and economic consequences associated with anastomotic leaks and diverting stomas, a $5B market opportunity. The company's lead product is a single-use, temporary intraluminal bypass device designed to protect the anastomotic site. With over 110 patients treated in clinical studies with excellent results and compelling surgeon feedback, Colospan has successfully received CE mark (MDR) and FDA IDE approval to launch a US pivotal study.

Therapeutic: Surgery; Colorectal

Comphya (Lausanne, VD, Switzerland) is developing the first implantable neurostimulator to restore erectile function in non-responders to oral drugs, a large underserved population. Our patented technology consists of a neurostimulator capable of activating the pro-erectile nerves to trigger physiological penile erection and/or rehabilitate erectile function post-prostatectomy. Our device offers a painless, non-traumatic, effective, and more spontaneous treatment option for ED patients.

Therapeutic: Neuromodulation-Neurostimulation; Urology

CorInnova (Texas Medical Center, Houston, Texas USA) has developed a revolutionary device for the treatment of heart failure promising to double the $5B market for short-term cardiac assist (< 5 days’ use) by treating the 50% of patients unable to use existing devices, including more women who receive only 25% of cardiac devices. The pneumatically driven device surrounds both ventricles and does not touch the blood, avoiding many blood-related adverse events. Air inflates the device synchronously with the heart, gently squeezing the heart for increased output and recovery.

Therapeutic: Cardiovascular; Mechanical circulatory support

endomina by Endo Tools Therapeutics (Charleroi, Belgium) is a commercially available suturing platform targeting endoscopic gastroplasty (for bariatric/metabolic surgery), reflux treatment and GI tumor resection. It has been succesfully used in more than 1000 procedures (mostly gastroplasty). It is cleared in the US and CE marked in Europe. This funding round aims at expanding clinical indications in the US and ramp up commercial activities.

Therapeutic: Gastroenterology; Obesity

EP Solutions is based in Switzerland and develops a noninvasive planning tool that will boost the success rate of cardiac resynchronisation therapy, or CRT. Today, this life-saving device therapy for heart failure patients with an electric conduction disorder is successful in only 70% of cases. We aim to significantly improve this number and improve patients’ lives while reducing the economic, clinical and personal cost of non-response. We intend to become the provider of choice for a routine CRT planning tool, that is proven to improve outcome.

Therapeutic: Cardiovascular

GrOwnValve GmbH (Berlin, Germany) revolutionizes heart valve replacement with a groundbreaking autologous procedure. Our technology enables the creation of personalized, growing heart valves from the patient's own tissue, using a unique catheter-based approach. Designed for a single operation, it promises a swift recovery, no visible scarring, and eliminates the need for lifelong medication. Focused on improving patient outcomes and quality of life, GrOwnValve represents a significant advancement in treating congenital and acquired heart valve diseases.

Therapeutic: Cardiovascular; Structural heart

Revolutionizing cartilage recovery: Hy2Care’s (Geleen, Limburg, the Netherlands) CartRevive™ hydrogel implant realizes optimal regeneration of cartilage defects. After sports mishaps, slips, or falls, our patented hydrogel offers a scaffold of joint-matching composition, guiding natural cell growth and enabling the body to heal itself. Currently under clinical examination in the Netherlands for EU approval, with US trials coming up. Dive into the future of joint repair with us!

Therapeutic: Orthopedics-Spine; Regenerative Medicine

InnovHeart (Newton, MA, USA & Milan, Italy) is an Italian company with global presence resulting from an office in the U.S. (Boston, MA) and a partnership in Greater China (GrandPharma). InnovHeart is developing a proprietary, unique TMVR system (Saturn) which addresses many of the challenges (LVOT obstruction, annular size and shape) identified by other companies in early feasibility studies focused on addressing mitral regurgitation (MR). Saturn technology is comprised of a sub-annular ring fully connected (interlocked) with a central valve. Two halves of the ring are delivered independently before being seated onto anterior and posterior valve connecting blocks. The system components (rings and valve) are all delivered over continuous rails providing for ease of use. Benefits are delivery of the valve prosthesis in the anatomically correct position establishing stable, durable anchoring and reverse remodeling of the mitral annulus improving heart function. The short height of the valve (13mm below the annular plane) reduces the potential for LVOT obstruction. InnovHeart has successfully implanted five trans-apical patients with two-year follow up on three patients and one year follow up on the last two. The company will begin a global trans-septal early feasibility study in late Q1 2024. InnovHeart is backed by leading investor Genextra S.p.A, Italian holding company specialized in early-stage investments in the life sciences sector, as well as Panakes Partners, Indaco Venture Capital, CDP Venture Capital and East Ocean (GrandPharma).

Therapeutic: Cardiovascular; Medical Device for Structural Heart

Keimon Medical (Trondheim, Trondelag, Norway) offers a device-based pain treatment drawing upon research conducted at one of Europe’s premier research centers specialising in headache and facial pain. The minimally invasive, high throughput, office-based approach is fully repeatable at pain re-occurrence and supersedes the current state of the art by better effect, better adverse event profile and lower cost. We are currently advancing a pipeline of candidate targets in multiple pain conditions to bring much needed pain relief where it is needed the most.

Therapeutic: Pain Management; Neuromodulation

KLISBio (Bresso, Milan, Italy) is a clinical-stage regenerative medicine company. We are developing innovative technology platforms based on silk fibroin, which allows for the creation of solutions for tissue repair and regeneration. The most advanced product is SILKBridge, a silk-based nerve guide, which is being prepared for commercial launch in US. Silk fibroin is biocompatible and promotes cell proliferation, stimulating in-vivo tissue regeneration. It provides a combination of outstanding biological and mechanical properties. Assets under development: vascular grafting, bone grafting, rotator cuff repair.

Therapeutic: Biomaterials

Lymphatica Medtech (Lausanne, Vaud, Switzerland) has developed, and clinically demonstrated in a positive FIH study, LymphoDrain: a revolutionary device for the treatment of lymphedema, a chronic condition with no cure affecting over 10 million patients in US and Europe.

Therapeutic: Cardiovascular

Nanoflex Robotics is developing a soft robotic platform for the remote vascular interventions. Our initial market is stroke, where we aim to increase patient access to time-sensitive and life-saving clot removal procedures and enable faster and safer procedures.

Therapeutic: Robotics; Neurovascular

Neuroelectrics pioneers brain stimulation and AI therapies for neurological diseases. Offering top-notch non-invasive electrical brain stimulation, they aim to restore brain health and enhance patients' lives. Founded in 2011 and headquartered in Barcelona and Boston, they distribute products globally for neuroscience and clinical research. Their vision is to create a versatile neurotechnology platform for improving countless lives through innovative clinical applications.

Therapeutic Category: Brain Stimulation

Orixha’s (Maisons-Alfort, France) mission is to develop Liquid Ventilation Medical Devices to save lives in Critical Care. Orixha develops Vent2Cool based on its proprietary Lung Conservative Liquid Ventilation to shield the critical organs (brain, heart) from reperfusion injury.  Vent2Cool improves survival and morbidity outcomes of Post Cardiac Arrest Syndrome by transforming the lungs into an efficient heat exchanger with the circulating blood to induce ultra-rapid therapeutic hypothermia – reaching the 33°C protective temperature within minutes vs. hours with current hypothermia devices. Orixha’s proprietary total liquid ventilation technology platform, once validated in therapeutic hypothermia, will be developed for other Critical Care conditions such as Acute Respiratory Distress Syndrome.

Therapeutic: Medical device / Intensive Care / Critical Care / Respiratory support

Phosphoenix (Amsterdam (North Holland, The Netherlands) is a Dutch MedTech start-up with a mission to restore lost vision through an innovative neuroprosthesis that bypasses the eyes and directly interfaces with the brain. Distinguished by its high resolution, expansive visual field coverage, and long-term durability, our revolutionary approach leverages existing technologies and established neurosurgical practices. Beyond vision restoration, our neuroprosthesis technology will enable other brain-based therapies, ranging from motor movement restoration to neuromodulation therapy.

Therapeutic: Neuromodulation-Neurostimulation

Preventicus (Jena, Thüringen, Germany) provides managed care programs and technology for cardiovascular disease through early detection, diagnosis and monitoring. Innovative telecare technology, clinical evidence and proven health-economic outcomes, in compliance with medical guidelines, offer value to patients and health insurances.

Therapeutic: Cardiovascular, Stroke

Pulnovo Medical (Shanghai, China) has developed, patented, registered the global first-in-class Pulmonary Artery Denervation (PADN®) therapeutic device to enhance the medical prognosis and improve quality of life for pulmonary hypertension and heart failure patients. For over a decade, Pulnovo has a leading position in PADN's therapeutic mechanism of action exploration, clinical data establishment, product development and commercialization.

Therapeutic: Cardiovascular; Interventional procedure

Sensome (Massy, France) is a clinical-stage start-up revolutionizing healthcare with its patented sensor technology. By combining the world's smallest impedance-based microsensors and machine learning, Sensome's technology identifies biological tissues in real-time, transforming invasive medical devices into connected healthcare devices. The first product, the Clotild® Smart Guidewire System, is undergoing clinical trials and has the potential to improve stroke treatment. Sensome's technology has applications beyond stroke, including peripheral vascular intervention and interventional oncology.

Therapeutic: Neurovascular

SentiAR’s (St Louis, MO) CommandEP system is world’s first and only FDA Approved holographic cardiac ablation guidance system. The system creates a holographic, patient specific digital twin in real time and provides physicians the ability to manipulate their views through a hands-free interface. Clinical studies have shown system can improve physician navigation accuracy as well as communication load in the room.

Therapeutic: Augmented Reality

STENTiT (Eindhoven, Noord-Brabant, the Netherlands) aims to prevent hundreds of thousands of amputations every single year, in the treatment of below-the-knee critical limb ischemia. Our solution is a regenerative stent, fully made from bioresobable nanofibers. This stent will not just only open the occluded artery, but even reconstruct a new blood vessel from the inside-out.

Therapeutic: Regenerative Medicine; Cardiovascular

In many fields of surgery, bone-cutting procedures involve the risk of complications caused by the surgical drill damaging vital soft tissues such as blood vessels or central nervous system structures. Such complications can severely affect patients' quality of life and result in significant costs. Surgify Halo by Surgify Medical (Espoo, Finland) is a tissue-selective bone-cutting technology that offers improved safety, precision, and speed during neurosurgical and orthopedic procedures. The novel product provides high accuracy and a unique soft-tissue protection shield for less-invasive surgery. The improved safety is delivered through Surgify Halo's patented safety mechanism, a tissue-selective safety shield around the burr, which activates automatically when the drill bit encounters tissue softer than bone during surgery. On the other hand, the cutting mode is activated when placed on bone or other hard tissue.

Therapeutic: Surgery

Our mission at SymPhysis Medical (Dublin rd., Galway, Connaught, Ireland) is to enhance the palliative care pathway to provide unrivalled patient independence and reduce hospitalisations for people with life-limiting cancers. releaze is our emergent technology to treat fluid build-up in the chest cavity caused by cancer. releaze is a user-centric drainage catheter system that allows patients to drain at home fully independently and incorporates an active patent-pending mechanism to accelerate time to catheter removal compared to current systems.

Therapeutic: Oncology/Palliative Care / Malignant Pleural Effusion

Syntropic Medical (Klosterneuburg, Austria) is developing a non-invasive, wearable device for the treatment of depression. By activating the immune cells of the brain with light delivered through the eyes, Syntropic can achieve faster and longer relief from symptoms and eliminate adverse drug reactions.

Therapeutic: Neuromodulation-Neurostimulation

WISE (Milano, Italy) is a medical device company that develops innovative electrodes for Neuromonitoring, Neuromodulation and BCI. Its proprietary Supersonic Technology allows the creation of stretchable and pliable electrodes that can conform to neural tissues and improve clinical outcomes. WISE's products include the Heron® lead, a unidirectional, percutaneous, multicolumn lead for Spinal Cord Stimulation, and the WISE Cortical Strip (WCS®), a single-use cortical electrode for IntraOperative Neurophysiological Monitoring.

Therapeutic: Neuromodulation-Neurostimulation; Neuromonitoring